The two players will miss the tie at the Theatre of Dreams due to yellow card accumulation.
This is a massive blow for the Phobians who are seeking for a crucial win in their Premier League title surge.
Coach Samuel Boadu must fashion out a ploy to beat Dreams without the influential duo.
Hearts of Oak are third on the table with 34 points from 21 matches.
The Phobians left it late to pick a point at Karela United last Sunday.
They thrashed second-tier side Nima Montreal 4-2 in a friendly on Tuesday as a warm up match.